Arginine⁃containing desensitization toothpaste for dentin hypersensitivity: a Meta analysis

• Main Authors: NIU Ying⁃Hu, LI Sha, Ma⁃Li⁃Ya⁃Mu⁃Gu⁃Li PATAER, ZHAO Jin
• Format: Article
• Language: zho
• Published: Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 2016-11-01
• Series: 口腔疾病防治
• Subjects: Arginine⁃containing desensitization toothpaste; Dentin hypersensitivity; Systematic review; Meta⁃ analysis; Randomized controlled trial
• Online Access: http://www.kqjbfz.com/EN/10.12016/j.issn.2096-1456.2016.11.002
• ISSN: 2096-1456; 2096-1456

Objective Meta analysis was used to evaluate and compare the efficacy of treatment of dentin hypersen⁃ sitivity with arginine desensitization toothpaste and commonly used desensitization toothpaste. Methods A computer⁃ ized search of Wanfang, PubMed, web of science, and Cochrane library databases was performed, and a manual retrieval was supplemented. Randomized control trials (RCT) about arginine⁃containing desensitization toothpaste for dentine hy⁃ persensitivity were collected, then data extraction and quality assessment were performed by 2 raters independently. Meta ⁃analysis was carried out by RevMan 5.3 software. Results A total of 7 RCTs were included. All the results were eval⁃ uated by the tactile sensitivity test and the air blast test. The mean and standard deviation of each treatment group were analyzed by the random effects model. Meta⁃analysis results showed there was statistical significance in the therapeutic effects between arginine⁃containing desensitization toothpaste and potassium⁃containing desensitization toothpaste(tac⁃ tile sensitivity test to evaluate: SMD = 1.83, 95% CI BP, 2.58], P < 0.05; cold air assessment: SMD = ⁃1.19, 95% CI [ ⁃ 1.69, ⁃ 0.69], P < 0.05); However, there was no statistical significance between arginine ⁃ containing desensitization toothpaste and strontium⁃containing desensitization toothpaste (tactile sensitivity test to evaluate: SMD = 0.68, 95% CI [⁃1.59, 2.96], P > 0.05; cold air assessment: SMD = ⁃0.94, 95% CI [⁃2.28, 0.40], P > 0.05). Conclusion It shows that arginine⁃containing desensitization toothpaste has greater effects than potassium⁃containing desensitization toothpaste for dentin hypersensitivity, but no better effects than strontium⁃containing desensitization toothpaste.