A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.

A rare case of B cell lymphoblastic leukemia with inv(7)(p15q34) with review of literature.

The inv(7)(p15q34) chromosomal abnormality which juxtaposes part of the HOXA gene cluster on 7p15 to the TCRβ locus on 7q34, has been described in a subset of cases of T-cell lymphoblastic leukemia, but its presence in cases of B-cell lymphoblastic leukemia is virtually unknown. Herewith, we report...

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Bibliographic Details
Main Authors: Bernhisel Andrew, Orazi Attilio, Guar Sumit, Tonk Vijay, Ghafouri Sayed Reshad, Padilla Osvaldo
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Leukemia Research Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048921000170
Description
Summary:The inv(7)(p15q34) chromosomal abnormality which juxtaposes part of the HOXA gene cluster on 7p15 to the TCRβ locus on 7q34, has been described in a subset of cases of T-cell lymphoblastic leukemia, but its presence in cases of B-cell lymphoblastic leukemia is virtually unknown. Herewith, we report a case of a B-cell lymphoblastic leukemia with inv(7)(p15q34). The patient received standard induction chemotherapy, which failed to produce remission. After treatment with blinatumomab, a bispecific T-cell engager, the follow-up bone marrow biopsy showed no evidence of persistent/ relapsed B-cell lymphoblastic leukemia. The unique cytogenetics of this case may have contributed to its resistance of standard induction chemotherapy.
ISSN:2213-0489

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