Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1

Histone deacetylase 3 promotes innate antiviral immunity through deacetylation of TBK1

Abstract TANK-binding kinase 1 (TBK1), a core kinase of antiviral pathways, activates the production of interferons (IFNs). It has been reported that deacetylation activates TBK1; however, the precise mechanism still remains to be uncovered. We show here that during the early stage of viral infectio...

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Bibliographic Details
Main Authors: Jie-lin Tang, Qi Yang, Chong-hui Xu, He Zhao, Ya-ling Liu, Can-yu Liu, Yuan Zhou, Dong-wei Gai, Rong-juan Pei, Yun Wang, Xue Hu, Bo Zhong, Yan-yi Wang, Xin-wen Chen, Ji-zheng Chen
Format: Article
Language:English
Published: SpringerOpen 2020-08-01
Series:Protein & Cell
Subjects:
TBK1
HDAC3
deacetylation
IRF3
innate immune
Online Access:https://doi.org/10.1007/s13238-020-00751-5

Internet

https://doi.org/10.1007/s13238-020-00751-5

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