The impact of different suturing techniques for abdominal fascia closure on the Interleukin-6 expressions in Rattus norvegicus

• Main Authors: Heryu Prima, Imam Sofii, Aditya Rifqi Fauzi, Ishandono Dachlan, Gunadi
• Format: Article
• Language: English
• Published: BMC 2020-10-01
• Series: BMC Research Notes
• Subjects: Abdominal fascial closure; Interleukin-6 expression; Incisional hernia; Large stitch; Small stitch
• Online Access: http://link.springer.com/article/10.1186/s13104-020-05349-y

Abstract Objective Incisional hernia is a frequent complication of midline laparotomy. The suturing technique is an important determinant of the risk of developing an incisional hernia. Moreover, IL-6 has crucial roles in the wound-healing process. We aimed to compare the large stitch vs. small stitch technique for abdominal fascial closure on IL-6 expressions in rats. Results Twenty rats were used. The small stitch group received small tissue bites of 5 mm and the large stitch group received large bites of 10 mm. The incisions of fascia were closed by running sutures. Animals were euthanized on days 4 and 7. Histological sections of the tissue-embedded sutures were analyzed for IL-6 expressions. Two-way ANOVA showed that rats in the small stitch group had similar IL-6 expressions on days 4 and 7 to those in the large stitch group (p = 0.36). In conclusion, the IL-6 expressions are similar between the small and the large stitch groups, implying that different suturing techniques might not have an impact on the incisional hernia occurrence.