Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Vps34-mediated macropinocytosis in Tuberous Sclerosis Complex 2-deficient cells supports tumorigenesis

Abstract Tuberous Sclerosis Complex (TSC), a rare genetic disorder with mechanistic target of rapamycin complex 1 (mTORC1) hyperactivation, is characterized by multi-organ hamartomatous benign tumors including brain, skin, kidney, and lung (Lymphangioleiomyomatosis). mTORC1 hyperactivation drives me...

Full description

Bibliographic Details
Main Authors: Harilaos Filippakis, Amine Belaid, Brian Siroky, Constance Wu, Nicola Alesi, Thomas Hougard, Julie Nijmeh, Hilaire C. Lam, Elizabeth P. Henske
Format: Article
Language:English
Published: Nature Publishing Group 2018-09-01
Series:Scientific Reports
Subjects:
Tuberous Sclerosis Complex
TSC2-deficient Cells
Dextran Uptake
Mouse Embryonic Fibroblasts (MEFs)
Ethylisopropylamiloride (EIPA)
Online Access:https://doi.org/10.1038/s41598-018-32256-x

Internet

https://doi.org/10.1038/s41598-018-32256-x

Similar Items