Pathological femoral fractures due to osteomalacia associated with adefovir dipivoxil treatment for hepatitis B: a case report

• Main Authors: Tanaka Motoyuki, Setoguchi Takao, Ishidou Yasuhiro, Arishima Yoshiya, Hirotsu Masataka, Saitoh Yoshinobu, Nakamura Shunsuke, Kakoi Hironori, Nagano Satoshi, Yokouchi Masahiro, Kamizono Junichi, Komiya Setsuro
• Format: Article
• Language: English
• Published: BMC 2012-08-01
• Series: Diagnostic Pathology
• Subjects: Osteomalacia; Pathological femoral neck fracture; Adefovir dipivoxil; Hepatitis B; Fanconi’s syndrome
• Online Access: http://www.diagnosticpathology.org/content/7/1/108
• ISSN: 1746-1596

<p>Abstract</p> <p>We present a case of a 62-year-old man who underwent total hip arthroplasty for treatment of pathologic femoral neck fracture associated with adefovir dipivoxil-induced osteomalacia. He had a 13-month history of bone pain involving his shoulders, hips, and knee. He received adefovir dipivoxil for treatment of lamivudine-resistant hepatitis B virus infection for 5 years before the occurrence of femoral neck fracture. Orthopedic surgeons should be aware of osteomalacia and pathological hip fracture caused by drug-induced renal dysfunction, which results in Fanconi’s syndrome.</p> <p>Virtual slides</p> <p>The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1600344696739249</p>