TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.

TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.

<h4>Aims</h4>We investigated the role of the TLR4-accessory molecule RP105 (CD180) in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical ana...

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Bibliographic Details
Main Authors: Antonius J N M Bastiaansen, Jacco C Karper, Anouk Wezel, Hetty C de Boer, Sabine M J Welten, Rob C M de Jong, Erna A B Peters, Margreet R de Vries, Annemarie M van Oeveren-Rietdijk, Anton Jan van Zonneveld, Jaap F Hamming, A Yaël Nossent, Paul H A Quax
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24945347/pdf/?tool=EBI

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https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24945347/pdf/?tool=EBI

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