Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets

Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets

Intracerebral hemorrhage (ICH) is associated with the highest mortality and morbidity despite only constituting approximately 10–15% of all strokes. Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal blood are responsible for its highly d...

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Main Authors: Xin Hu, Chuanyuan Tao, Qi Gan, Jun Zheng, Hao Li, Chao You
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/3215391
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spelling doaj-65abf323f9f4493b983436d10f61bff42020-11-24T22:36:30ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/32153913215391Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic TargetsXin Hu0Chuanyuan Tao1Qi Gan2Jun Zheng3Hao Li4Chao You5Department of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaDepartment of Neurosurgery, West China Hospital, Sichuan University, 37 Guoxue Alley, Chengdu, Sichuan 610041, ChinaIntracerebral hemorrhage (ICH) is associated with the highest mortality and morbidity despite only constituting approximately 10–15% of all strokes. Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal blood are responsible for its highly damaging effects. Oxidative stress (OS) also plays an important role in brain injury after ICH but attracts less attention than other factors. Increasing evidence has demonstrated that the metabolite axis of hemoglobin-heme-iron is the key contributor to oxidative brain damage after ICH, although other factors, such as neuroinflammation and prooxidases, are involved. This review will discuss the sources, possible molecular mechanisms, and potential therapeutic targets of OS in ICH.http://dx.doi.org/10.1155/2016/3215391
collection DOAJ
language English
format Article
sources DOAJ
author Xin Hu
Chuanyuan Tao
Qi Gan
Jun Zheng
Hao Li
Chao You
spellingShingle Xin Hu
Chuanyuan Tao
Qi Gan
Jun Zheng
Hao Li
Chao You
Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets
Oxidative Medicine and Cellular Longevity
author_facet Xin Hu
Chuanyuan Tao
Qi Gan
Jun Zheng
Hao Li
Chao You
author_sort Xin Hu
title Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets
title_short Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets
title_full Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets
title_fullStr Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets
title_full_unstemmed Oxidative Stress in Intracerebral Hemorrhage: Sources, Mechanisms, and Therapeutic Targets
title_sort oxidative stress in intracerebral hemorrhage: sources, mechanisms, and therapeutic targets
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2016-01-01
description Intracerebral hemorrhage (ICH) is associated with the highest mortality and morbidity despite only constituting approximately 10–15% of all strokes. Complex underlying mechanisms consisting of cytotoxic, excitotoxic, and inflammatory effects of intraparenchymal blood are responsible for its highly damaging effects. Oxidative stress (OS) also plays an important role in brain injury after ICH but attracts less attention than other factors. Increasing evidence has demonstrated that the metabolite axis of hemoglobin-heme-iron is the key contributor to oxidative brain damage after ICH, although other factors, such as neuroinflammation and prooxidases, are involved. This review will discuss the sources, possible molecular mechanisms, and potential therapeutic targets of OS in ICH.
url http://dx.doi.org/10.1155/2016/3215391
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AT chuanyuantao oxidativestressinintracerebralhemorrhagesourcesmechanismsandtherapeutictargets
AT qigan oxidativestressinintracerebralhemorrhagesourcesmechanismsandtherapeutictargets
AT junzheng oxidativestressinintracerebralhemorrhagesourcesmechanismsandtherapeutictargets
AT haoli oxidativestressinintracerebralhemorrhagesourcesmechanismsandtherapeutictargets
AT chaoyou oxidativestressinintracerebralhemorrhagesourcesmechanismsandtherapeutictargets
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