| Summary: | Wine is an alcoholic drink, largely used to accompany food, with a key role in the protective effects on cardiovascular diseases. This study was developed to investigate radioisotopes and heavy metal content of twenty red, rose and white Italian wines, belonging to controlled origin denomination (DOC) geographic areas of the Calabria region, south of Italy. High Purity Germanium (HPGe) Gamma Spectrometry was employed to evaluate anthropogenic (<sup>137</sup>Cs) and natural (<sup>40</sup>K) radionuclides specific activity. Inductively Coupled Plasma Mass Spectrometry (ICP-MS) was used to assess any possible heavy metals contamination by a comparison between Cu, Zn, Pb, B, As and Cd concentrations with the limits set by the Italian Legislation. Calculated annual effective doses due to the ingestion of investigated samples are under allowable levels (1 mSv/year), thus excluding the risk of ionizing radiation effects on humans. Regarding to the metals concentration, experimental results show that they are lower than the contamination threshold values, thus excluding their presence as pollutants.
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