Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma

Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disru...

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Main Authors: Jiaqiang Dong, Jiong Li, Yang Li, Zhikun Ma, Yongxin Yu, Cun-Yu Wang
Format: Article
Language:English
Published: Nature Publishing Group 2021-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-24137-1
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spelling doaj-65a0996e08e9453696eacebfb20753992021-06-27T11:12:44ZengNature Publishing GroupNature Communications2041-17232021-06-0112111410.1038/s41467-021-24137-1Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinomaJiaqiang Dong0Jiong Li1Yang Li2Zhikun Ma3Yongxin Yu4Cun-Yu Wang5Jonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLADepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth UniversityJonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLADepartment of Medicinal Chemistry, School of Pharmacy, Virginia Commonwealth UniversityJonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLAJonsson Comprehensive Cancer Center and Broad Stem Cell Research Center, UCLALittle is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disrupting SEs inhibited CSC self-renewal and eliminated CSCs.https://doi.org/10.1038/s41467-021-24137-1
collection DOAJ
language English
format Article
sources DOAJ
author Jiaqiang Dong
Jiong Li
Yang Li
Zhikun Ma
Yongxin Yu
Cun-Yu Wang
spellingShingle Jiaqiang Dong
Jiong Li
Yang Li
Zhikun Ma
Yongxin Yu
Cun-Yu Wang
Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
Nature Communications
author_facet Jiaqiang Dong
Jiong Li
Yang Li
Zhikun Ma
Yongxin Yu
Cun-Yu Wang
author_sort Jiaqiang Dong
title Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_short Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_full Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_fullStr Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_full_unstemmed Transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
title_sort transcriptional super-enhancers control cancer stemness and metastasis genes in squamous cell carcinoma
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2021-06-01
description Little is known on the transcriptional mechanisms that control cancer stem cell (CSC) self-renewal and stemness. Here the authors show superenhancers (SEs) play a role in the transcription of cancer stemness genes as well as prometastatic genes, thereby controlling their tumorigenic potential; disrupting SEs inhibited CSC self-renewal and eliminated CSCs.
url https://doi.org/10.1038/s41467-021-24137-1
work_keys_str_mv AT jiaqiangdong transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
AT jiongli transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
AT yangli transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
AT zhikunma transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
AT yongxinyu transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
AT cunyuwang transcriptionalsuperenhancerscontrolcancerstemnessandmetastasisgenesinsquamouscellcarcinoma
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