Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline

Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline

Malaria-related hemophagocytic lymphohistiocytosis is a rare, potentially fatal, hyperinflammatory disease entity which can be challenging to diagnose and treat. It is usually associated with Plasmodium falciparum infection. It is less frequently associated with Plasmodium vivax. Here we report an u...

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Main Authors: Sawsan Amireh, Hamid Shaaban, Gunwant Guron
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Hematology/Oncology and Stem Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S1658387616300358
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spelling doaj-659921b3357546129c6f19da1ff689d22020-11-25T01:04:25ZengElsevierHematology/Oncology and Stem Cell Therapy1658-38762018-03-011113437Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycyclineSawsan Amireh0Hamid Shaaban1Gunwant Guron2Internal Medicine Department and Department of Hematology and Oncology, Saint Michael’s Medical Center, Newark, NJ, USACorresponding author at: Department of Hematology and Oncology, Saint Michael’s Medical Center, New York Medical College, 111 Central Avenue, Newark, NJ 07102, USA.; Internal Medicine Department and Department of Hematology and Oncology, Saint Michael’s Medical Center, Newark, NJ, USAInternal Medicine Department and Department of Hematology and Oncology, Saint Michael’s Medical Center, Newark, NJ, USAMalaria-related hemophagocytic lymphohistiocytosis is a rare, potentially fatal, hyperinflammatory disease entity which can be challenging to diagnose and treat. It is usually associated with Plasmodium falciparum infection. It is less frequently associated with Plasmodium vivax. Here we report an unusual case of a 23-year-old healthy Nigerian man who presented with fever, microangiopathic hemolytic anemia, acute renal failure, and confusion, and was diagnosed as having cerebral malaria-related hemophagocytic lymphohistiocytosis caused by P. vivax infection. He was successfully treated with intravenous artesunate and doxycycline with dramatic clinical improvement. Keywords: Plasmodium vivax, Malaria, Hemophagocytic lymphohistiocytosis, Artesunate, Doxycyclinehttp://www.sciencedirect.com/science/article/pii/S1658387616300358
collection DOAJ
language English
format Article
sources DOAJ
author Sawsan Amireh
Hamid Shaaban
Gunwant Guron
spellingShingle Sawsan Amireh
Hamid Shaaban
Gunwant Guron
Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
Hematology/Oncology and Stem Cell Therapy
author_facet Sawsan Amireh
Hamid Shaaban
Gunwant Guron
author_sort Sawsan Amireh
title Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
title_short Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
title_full Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
title_fullStr Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
title_full_unstemmed Severe Plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
title_sort severe plasmodium vivax cerebral malaria complicated by hemophagocytic lymphohistiocytosis treated with artesunate and doxycycline
publisher Elsevier
series Hematology/Oncology and Stem Cell Therapy
issn 1658-3876
publishDate 2018-03-01
description Malaria-related hemophagocytic lymphohistiocytosis is a rare, potentially fatal, hyperinflammatory disease entity which can be challenging to diagnose and treat. It is usually associated with Plasmodium falciparum infection. It is less frequently associated with Plasmodium vivax. Here we report an unusual case of a 23-year-old healthy Nigerian man who presented with fever, microangiopathic hemolytic anemia, acute renal failure, and confusion, and was diagnosed as having cerebral malaria-related hemophagocytic lymphohistiocytosis caused by P. vivax infection. He was successfully treated with intravenous artesunate and doxycycline with dramatic clinical improvement. Keywords: Plasmodium vivax, Malaria, Hemophagocytic lymphohistiocytosis, Artesunate, Doxycycline
url http://www.sciencedirect.com/science/article/pii/S1658387616300358
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AT hamidshaaban severeplasmodiumvivaxcerebralmalariacomplicatedbyhemophagocyticlymphohistiocytosistreatedwithartesunateanddoxycycline
AT gunwantguron severeplasmodiumvivaxcerebralmalariacomplicatedbyhemophagocyticlymphohistiocytosistreatedwithartesunateanddoxycycline
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