Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster

Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster

Abstract Background Nocamycins I and II, produced by the rare actinomycete Saccharothrix syringae, belong to the tetramic acid family natural products. Nocamycins show potent antimicrobial activity and they hold great potential for antibacterial agent design. However, up to now, little is known abou...

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Bibliographic Details
Main Authors: Xuhua Mo, Chunrong Shi, Chun Gui, Yanjiao Zhang, Jianhua Ju, Qingji Wang
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Microbial Cell Factories
Subjects:
Nocamycins
Biosynthetic gene cluster
Cytochrome P450 oxidase
Post-tailoring modification
Saccharothrix syringae
Online Access:http://link.springer.com/article/10.1186/s12934-017-0718-5

Internet

http://link.springer.com/article/10.1186/s12934-017-0718-5

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