Developmental Mutators and Early Onset Cancer

Developmental Mutators and Early Onset Cancer

A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.

Bibliographic Details
Main Authors: Alex Kentsis, Steven A. Frank
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Pediatrics
Subjects:
cancer genetics and genomics
developmental plasticity
mosaicism
childhood cancer
prevention
Online Access:https://www.frontiersin.org/article/10.3389/fped.2020.00189/full
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spelling doaj-65921a2040974f629c11d472f6441ced2020-11-25T03:27:51ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602020-04-01810.3389/fped.2020.00189538183Developmental Mutators and Early Onset CancerAlex Kentsis0Steven A. Frank1Sloan Kettering Institute and Department of Pediatrics, Weill Medical College of Cornell University and Memorial Sloan Kettering Cancer Center, New York, NY, United StatesDepartment of Ecology and Evolutionary Biology, University of California, Irvine, Irvine, CA, United StatesA new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.https://www.frontiersin.org/article/10.3389/fped.2020.00189/fullcancer genetics and genomicsdevelopmental plasticitymosaicismchildhood cancerprevention
collection DOAJ
language English
format Article
sources DOAJ
author Alex Kentsis
Steven A. Frank
spellingShingle Alex Kentsis
Steven A. Frank
Developmental Mutators and Early Onset Cancer
Frontiers in Pediatrics
cancer genetics and genomics
developmental plasticity
mosaicism
childhood cancer
prevention
author_facet Alex Kentsis
Steven A. Frank
author_sort Alex Kentsis
title Developmental Mutators and Early Onset Cancer
title_short Developmental Mutators and Early Onset Cancer
title_full Developmental Mutators and Early Onset Cancer
title_fullStr Developmental Mutators and Early Onset Cancer
title_full_unstemmed Developmental Mutators and Early Onset Cancer
title_sort developmental mutators and early onset cancer
publisher Frontiers Media S.A.
series Frontiers in Pediatrics
issn 2296-2360
publishDate 2020-04-01
description A new hypothesis suggests that somatic genome remodeling during normal development can cause mutations that explain many early onset cancers in children and adults.
topic cancer genetics and genomics
developmental plasticity
mosaicism
childhood cancer
prevention
url https://www.frontiersin.org/article/10.3389/fped.2020.00189/full
work_keys_str_mv AT alexkentsis developmentalmutatorsandearlyonsetcancer
AT stevenafrank developmentalmutatorsandearlyonsetcancer
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