Encryption of agonistic motifs for TLR4 into artificial antigens augmented the maturation of antigen-presenting cells.

Adjuvants are indispensable for achieving a sufficient immune response from vaccinations. From a functional viewpoint, adjuvants are classified into two categories: "physical adjuvants" increase the efficacy of antigen presentation by antigen-presenting cells (APC) and "signal adjuvan...

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Bibliographic Details
Main Authors: Masaki Ito, Kazumi Hayashi, Tamiko Minamisawa, Sadamu Homma, Shigeo Koido, Kiyotaka Shiba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5708714?pdf=render