Discovery of Icotinib-1,2,3-Triazole Derivatives as IDO1 Inhibitors

Tumor immunotherapy is considered to be a highlight in cancer treatment in recent years. Indoleamine 2,3-dioxygenase 1 (IDO1) is closely related to the over expression of many cancers, and is therefore a promising target for tumor immunotherapy. To search for novel IDO1-targeting therapeutic agents,...

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Bibliographic Details
Main Authors: Long-fei Mao, Yu-wei Wang, Jie Zhao, Gui-qing Xu, Xiao-jun Yao, Yue-Ming Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.579024/full