Halting the Allergic March

Halting the Allergic March

The prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact envi...

Full description

Bibliographic Details
Main Authors: Hugo P. Van Bever, MD, PhD, Sudesh T. Samuel, RPH, MHSM, Bee Wah Lee, MD
Format: Article
Language:English
Published: Elsevier 2008-01-01
Series:World Allergy Organization Journal
Online Access:http://www.sciencedirect.com/science/article/pii/S1939455119305769
id doaj-657f70160b58430180bfceccbde35063
record_format Article
spelling doaj-657f70160b58430180bfceccbde350632020-11-25T01:27:47ZengElsevierWorld Allergy Organization Journal1939-45512008-01-01145762Halting the Allergic MarchHugo P. Van Bever, MD, PhD0Sudesh T. Samuel, RPH, MHSM1Bee Wah Lee, MD2Corresponding author.; Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Rd, 119074 Singapore, SingaporeDepartment of Paediatrics, National University Hospital, 5 Lower Kent Ridge Rd, 119074 Singapore, SingaporeDepartment of Paediatrics, National University Hospital, 5 Lower Kent Ridge Rd, 119074 Singapore, SingaporeThe prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact environmental causes for the increase of allergic diseases have not yet been identified, but most researchers agree that a decreased bacterial load in young children may be one of the reasons for the increase. However, the causes of allergy are multiple, and the development of an allergic disease is the result of complex interactions between genetic constitution and environmental factors. In this review article, different aspects of allergic sensitization are covered, including prenatal and postnatal sensitization. The phenomenon of the ''allergic march'' (switching from one clinical expression of allergy to another) and its underlying mechanisms are discussed. The last part of this review article is on prevention and treatment of allergic diseases, including the role of bacterial products (probiotics, prebiotics, and synbiotics) and the role of immunotherapy, including sublingual immunotherapy. Keywords: review, allergy, children, allergic march, probiotics, immunotherapyhttp://www.sciencedirect.com/science/article/pii/S1939455119305769
collection DOAJ
language English
format Article
sources DOAJ
author Hugo P. Van Bever, MD, PhD
Sudesh T. Samuel, RPH, MHSM
Bee Wah Lee, MD
spellingShingle Hugo P. Van Bever, MD, PhD
Sudesh T. Samuel, RPH, MHSM
Bee Wah Lee, MD
Halting the Allergic March
World Allergy Organization Journal
author_facet Hugo P. Van Bever, MD, PhD
Sudesh T. Samuel, RPH, MHSM
Bee Wah Lee, MD
author_sort Hugo P. Van Bever, MD, PhD
title Halting the Allergic March
title_short Halting the Allergic March
title_full Halting the Allergic March
title_fullStr Halting the Allergic March
title_full_unstemmed Halting the Allergic March
title_sort halting the allergic march
publisher Elsevier
series World Allergy Organization Journal
issn 1939-4551
publishDate 2008-01-01
description The prevalence of childhood allergic diseases, such as allergic asthma, allergic rhinitis, and atopic dermatitis, has increased exponentially. In Singapore, the prevalence of asthma at all ages exceeds 20%, and around 50% of Singaporean children show features of an underlying allergy. The exact environmental causes for the increase of allergic diseases have not yet been identified, but most researchers agree that a decreased bacterial load in young children may be one of the reasons for the increase. However, the causes of allergy are multiple, and the development of an allergic disease is the result of complex interactions between genetic constitution and environmental factors. In this review article, different aspects of allergic sensitization are covered, including prenatal and postnatal sensitization. The phenomenon of the ''allergic march'' (switching from one clinical expression of allergy to another) and its underlying mechanisms are discussed. The last part of this review article is on prevention and treatment of allergic diseases, including the role of bacterial products (probiotics, prebiotics, and synbiotics) and the role of immunotherapy, including sublingual immunotherapy. Keywords: review, allergy, children, allergic march, probiotics, immunotherapy
url http://www.sciencedirect.com/science/article/pii/S1939455119305769
work_keys_str_mv AT hugopvanbevermdphd haltingtheallergicmarch
AT sudeshtsamuelrphmhsm haltingtheallergicmarch
AT beewahleemd haltingtheallergicmarch
_version_ 1725103241638707200

Similar Items