Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept

Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept

Ankylosing spondylitis (AS) is presented with axial and peripheral articular involvement. Uveitis is a severe and rather specific manifestation of AS. Biologics targeting tumor necrosis factor (TNF) α are effective on both articular and ocular manifestations of disease. The occurrence of uveitis in...

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Main Authors: Bernd Raffeiner, Francesca Ometto, Livio Bernardi, Costantino Botsios, Leonardo Punzi
Format: Article
Language:English
Published: Hindawi Limited 2014-01-01
Series:Case Reports in Medicine
Online Access:http://dx.doi.org/10.1155/2014/471319
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spelling doaj-657e738d381c41318837cf010216a2702020-11-24T22:36:30ZengHindawi LimitedCase Reports in Medicine1687-96271687-96352014-01-01201410.1155/2014/471319471319Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with EtanerceptBernd Raffeiner0Francesca Ometto1Livio Bernardi2Costantino Botsios3Leonardo Punzi4Rheumatology Unit, Department of Medicine, General Hospital of Bolzano, Lorenz Boehler Street No. 5, 39100 Bolzano, ItalyRheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyRheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyRheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyRheumatology Unit, Department of Medicine, University of Padova, 35128 Padova, ItalyAnkylosing spondylitis (AS) is presented with axial and peripheral articular involvement. Uveitis is a severe and rather specific manifestation of AS. Biologics targeting tumor necrosis factor (TNF) α are effective on both articular and ocular manifestations of disease. The occurrence of uveitis in patients that never had eye involvement or the relapse of uveitis is described during anti-TNFα treatment. The frequency of these events is slightly higher during therapy with etanercept. The available TNFα blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects. There is an ongoing debate whether uveitis during anti-TNFα has to be considered as paradoxical effect or an inadequate response to therapy. Here, we present a case report and review what the evidences for the two hypotheses are.http://dx.doi.org/10.1155/2014/471319
collection DOAJ
language English
format Article
sources DOAJ
author Bernd Raffeiner
Francesca Ometto
Livio Bernardi
Costantino Botsios
Leonardo Punzi
spellingShingle Bernd Raffeiner
Francesca Ometto
Livio Bernardi
Costantino Botsios
Leonardo Punzi
Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
Case Reports in Medicine
author_facet Bernd Raffeiner
Francesca Ometto
Livio Bernardi
Costantino Botsios
Leonardo Punzi
author_sort Bernd Raffeiner
title Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
title_short Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
title_full Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
title_fullStr Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
title_full_unstemmed Inefficacy or Paradoxical Effect? Uveitis in Ankylosing Spondylitis Treated with Etanercept
title_sort inefficacy or paradoxical effect? uveitis in ankylosing spondylitis treated with etanercept
publisher Hindawi Limited
series Case Reports in Medicine
issn 1687-9627
1687-9635
publishDate 2014-01-01
description Ankylosing spondylitis (AS) is presented with axial and peripheral articular involvement. Uveitis is a severe and rather specific manifestation of AS. Biologics targeting tumor necrosis factor (TNF) α are effective on both articular and ocular manifestations of disease. The occurrence of uveitis in patients that never had eye involvement or the relapse of uveitis is described during anti-TNFα treatment. The frequency of these events is slightly higher during therapy with etanercept. The available TNFα blockers show different pharmacokinetics and pharmacodynamics yielding different biological effects. There is an ongoing debate whether uveitis during anti-TNFα has to be considered as paradoxical effect or an inadequate response to therapy. Here, we present a case report and review what the evidences for the two hypotheses are.
url http://dx.doi.org/10.1155/2014/471319
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