Mechanisms of DNA Methyltransferase Recruitment in Mammals

DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment and activation of de novo and maintenance DNA methyltransfe...

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Main Authors:	Marthe Laisné, Nikhil Gupta, Olivier Kirsh, Sriharsa Pradhan, Pierre-Antoine Defossez
Format:	Article
Language:	English
Published:	MDPI AG 2018-12-01
Series:	Genes
Subjects:	epigenetics DNA methylation DNA methyltransferases
Online Access:	https://www.mdpi.com/2073-4425/9/12/617

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spelling	doaj-6578a708978443c0aad48e0d08b121c42020-11-24T21:28:33ZengMDPI AGGenes2073-44252018-12-0191261710.3390/genes9120617genes9120617Mechanisms of DNA Methyltransferase Recruitment in MammalsMarthe Laisné0Nikhil Gupta1Olivier Kirsh2Sriharsa Pradhan3Pierre-Antoine Defossez4Epigenetics and Cell Fate, UMR7216 CNRS, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceEpigenetics and Cell Fate, UMR7216 CNRS, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceEpigenetics and Cell Fate, UMR7216 CNRS, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceNew England Biolabs, 240 County Rd, Ipswich, MA 01938, USAEpigenetics and Cell Fate, UMR7216 CNRS, University Paris Diderot, Sorbonne Paris Cité, 75013 Paris, FranceDNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment and activation of de novo and maintenance DNA methyltransferases (DNMTs). In this review, we discuss mechanisms of recruitment of DNMTs by transcription factors and chromatin modifiers—and by RNA—and place these mechanisms in the context of biologically meaningful epigenetic events. We present hypotheses and speculations for future research, and underline the fundamental and practical benefits of better understanding the mechanisms that govern the recruitment of DNMTs.https://www.mdpi.com/2073-4425/9/12/617epigeneticsDNA methylationDNA methyltransferases
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marthe Laisné Nikhil Gupta Olivier Kirsh Sriharsa Pradhan Pierre-Antoine Defossez
spellingShingle	Marthe Laisné Nikhil Gupta Olivier Kirsh Sriharsa Pradhan Pierre-Antoine Defossez Mechanisms of DNA Methyltransferase Recruitment in Mammals Genes epigenetics DNA methylation DNA methyltransferases
author_facet	Marthe Laisné Nikhil Gupta Olivier Kirsh Sriharsa Pradhan Pierre-Antoine Defossez
author_sort	Marthe Laisné
title	Mechanisms of DNA Methyltransferase Recruitment in Mammals
title_short	Mechanisms of DNA Methyltransferase Recruitment in Mammals
title_full	Mechanisms of DNA Methyltransferase Recruitment in Mammals
title_fullStr	Mechanisms of DNA Methyltransferase Recruitment in Mammals
title_full_unstemmed	Mechanisms of DNA Methyltransferase Recruitment in Mammals
title_sort	mechanisms of dna methyltransferase recruitment in mammals
publisher	MDPI AG
series	Genes
issn	2073-4425
publishDate	2018-12-01
description	DNA methylation is an essential epigenetic mark in mammals. The proper distribution of this mark depends on accurate deposition and maintenance mechanisms, and underpins its functional role. This, in turn, depends on the precise recruitment and activation of de novo and maintenance DNA methyltransferases (DNMTs). In this review, we discuss mechanisms of recruitment of DNMTs by transcription factors and chromatin modifiers—and by RNA—and place these mechanisms in the context of biologically meaningful epigenetic events. We present hypotheses and speculations for future research, and underline the fundamental and practical benefits of better understanding the mechanisms that govern the recruitment of DNMTs.
topic	epigenetics DNA methylation DNA methyltransferases
url	https://www.mdpi.com/2073-4425/9/12/617
work_keys_str_mv	AT marthelaisne mechanismsofdnamethyltransferaserecruitmentinmammals AT nikhilgupta mechanismsofdnamethyltransferaserecruitmentinmammals AT olivierkirsh mechanismsofdnamethyltransferaserecruitmentinmammals AT sriharsapradhan mechanismsofdnamethyltransferaserecruitmentinmammals AT pierreantoinedefossez mechanismsofdnamethyltransferaserecruitmentinmammals
_version_	1725969816447090688

Mechanisms of DNA Methyltransferase Recruitment in Mammals

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