A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response

A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response

The clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immu...

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Main Authors: A. Ari Hakimi, Kyrollis Attalla, Renzo G. DiNatale, Irina Ostrovnaya, Jessica Flynn, Kyle A. Blum, Yasser Ged, Douglas Hoen, Sviatoslav M. Kendall, Ed Reznik, Anita Bowman, Jason Hwee, Christopher J. Fong, Fengshen Kuo, Martin H. Voss, Timothy A. Chan, Robert J. Motzer
Format: Article
Language:English
Published: Nature Publishing Group 2020-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-17965-0
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spelling doaj-655ac0280dd44b29884b0203c1be1bd42021-08-22T11:41:41ZengNature Publishing GroupNature Communications2041-17232020-08-0111111110.1038/s41467-020-17965-0A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy responseA. Ari Hakimi0Kyrollis Attalla1Renzo G. DiNatale2Irina Ostrovnaya3Jessica Flynn4Kyle A. Blum5Yasser Ged6Douglas Hoen7Sviatoslav M. Kendall8Ed Reznik9Anita Bowman10Jason Hwee11Christopher J. Fong12Fengshen Kuo13Martin H. Voss14Timothy A. Chan15Robert J. Motzer16Urology Service, Department of Surgery, Memorial Sloan Kettering Cancer CenterUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer CenterUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterUrology Service, Department of Surgery, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterImmunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer CenterDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterComputational Oncology Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterDepartment of Pathology, Memorial Sloan Kettering Cancer CenterHuman Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer CenterImmunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterImmunogenomics and Precision Oncology Platform, Memorial Sloan Kettering Cancer CenterDepartment of Medicine, Memorial Sloan Kettering Cancer CenterThe clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immune-checkpoint blockade.https://doi.org/10.1038/s41467-020-17965-0
collection DOAJ
language English
format Article
sources DOAJ
author A. Ari Hakimi
Kyrollis Attalla
Renzo G. DiNatale
Irina Ostrovnaya
Jessica Flynn
Kyle A. Blum
Yasser Ged
Douglas Hoen
Sviatoslav M. Kendall
Ed Reznik
Anita Bowman
Jason Hwee
Christopher J. Fong
Fengshen Kuo
Martin H. Voss
Timothy A. Chan
Robert J. Motzer
spellingShingle A. Ari Hakimi
Kyrollis Attalla
Renzo G. DiNatale
Irina Ostrovnaya
Jessica Flynn
Kyle A. Blum
Yasser Ged
Douglas Hoen
Sviatoslav M. Kendall
Ed Reznik
Anita Bowman
Jason Hwee
Christopher J. Fong
Fengshen Kuo
Martin H. Voss
Timothy A. Chan
Robert J. Motzer
A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
Nature Communications
author_facet A. Ari Hakimi
Kyrollis Attalla
Renzo G. DiNatale
Irina Ostrovnaya
Jessica Flynn
Kyle A. Blum
Yasser Ged
Douglas Hoen
Sviatoslav M. Kendall
Ed Reznik
Anita Bowman
Jason Hwee
Christopher J. Fong
Fengshen Kuo
Martin H. Voss
Timothy A. Chan
Robert J. Motzer
author_sort A. Ari Hakimi
title A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_short A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_full A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_fullStr A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_full_unstemmed A pan-cancer analysis of PBAF complex mutations and their association with immunotherapy response
title_sort pan-cancer analysis of pbaf complex mutations and their association with immunotherapy response
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-08-01
description The clinical benefit from immunotherapy response in patients with mutations of genes forming the chromatin remodelling complex PBAF remains controversial. Here the authors show that PBAF complex mutations are not associated with favourable response in pan-cancer cohorts of patients treated with immune-checkpoint blockade.
url https://doi.org/10.1038/s41467-020-17965-0
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