Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression

Resveratrol reverses morphine-induced neuroinflammation in morphine-tolerant rats by reversal HDAC1 expression

We previously showed that subsequent intrathecal (i.t.) injection of resveratrol (30 μg) significantly reverses morphine-evoked neuroinflammation in morphine-tolerant rats. The present study examined the underlying mechanism. Methods: Male Wistar rats were implanted with two i.t. catheters, one of w...

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Bibliographic Details
Main Authors: Ru-Yin Tsai, Juei-Chii Wang, Kuang-Yi Chou, Chih-Shung Wong, Chen-Hwan Cherng
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Journal of the Formosan Medical Association
Subjects:
epigenetic
intrathecal
opioid
spinal
Online Access:http://www.sciencedirect.com/science/article/pii/S0929664615001801

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