Intracellular Delivery of siRNAs Targeting AKT and ERBB2 Genes Enhances Chemosensitization of Breast Cancer Cells in a Culture and Animal Model

Intracellular Delivery of siRNAs Targeting AKT and ERBB2 Genes Enhances Chemosensitization of Breast Cancer Cells in a Culture and Animal Model

Pharmacotherapy as the mainstay in the management of breast cancer suffers from various drawbacks, including non-targeted biodistribution, narrow therapeutic and safety windows, and also resistance to treatment. Thus, alleviation of the constraints from the pharmacodynamic and pharmacokinetic profil...

Full description

Bibliographic Details
Main Authors: Tahereh Fatemian, Hamid Reza Moghimi, Ezharul Hoque Chowdhury
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Pharmaceutics
Subjects:
siRNA
drug delivery
nanoparticle
carbonate apatite
ERBB2
AKT
breast cancer
Online Access:https://www.mdpi.com/1999-4923/11/9/458

Similar Items

Similar Items