Artificial intelligence versus statistical modeling and optimization of continuous bead milling process for bacterial cell lysis

Artificial intelligence versus statistical modeling and optimization of continuous bead milling process for bacterial cell lysis

AbstractFor a commercially viable recombinant intracellular protein production process, efficient cell lysis and protein release is a major bottleneck. The recovery of recombinant protein, cholesterol oxidase (COD) was studied in a continuous bead milling process. A full factorial Response Surface M...

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Bibliographic Details
Main Authors: Shafiul Haque, Saif Khan, Mohd Wahid, Sajad Ahmad Dar, Nipunjot Soni, Raju Kumar Mandal, Vineeta Singh, Dileep Tiwari, Mohtashim Lohani, Mohammed Y. Areeshi, Thavendran Govender, Gert Kruger, ARSHAD JAWED
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-11-01
Series:Frontiers in Microbiology
Subjects:
Cholesterol Oxidase
cell lysis
artificial neural network
Genetic Algorithm
Central composite design
Response Surface Methodology
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01852/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01852/full

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