CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter

CD28 Individual Signaling Up-regulates Human IL-17A Expression by Promoting the Recruitment of RelA/NF-κB and STAT3 Transcription Factors on the Proximal Promoter

CD28 is an important co-stimulatory receptor for T lymphocytes that, in humans, delivers TCR-independent signal leading to the up-regulation of pro-inflammatory cytokines. We have recently reported that CD28 autonomous signaling induces the expression of IL-17A in peripheral CD4+ T lymphocytes from...

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Bibliographic Details
Main Authors: Martina Kunkl, Marta Mastrogiovanni, Nicla Porciello, Silvana Caristi, Emanuele Monteleone, Stefano Arcieri, Loretta Tuosto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Immunology
Subjects:
T lymphocytes
IL-17 A
CD28
NF-kappa B
STAT3
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00864/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00864/full

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