The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens α-toxins⃞

The relationship between the metabolism of sphingomyelin species and the hemolysis of sheep erythrocytes induced by Clostridium perfringens α-toxins⃞

Clostridium perfringens α-toxin induces the hemolysis of sheep erythrocytes by activating the metabolism of sphingomyelin (SM) via a GTP binding protein in membranes. α-Toxin stimulated the formation of 15-N-nervonoyl sphingosine (C24:1-ceramide), which was identified by positive ion fast atom bomba...

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Bibliographic Details
Main Authors: Masataka Oda, Takayuki Matsuno, Ryouta Shiihara, Sadayuki Ochi, Rieko Yamauchi, Yuki Saito, Hiroshi Imagawa, Masahiro Nagahama, Mugio Nishizawa, Jun Sakurai
Format: Article
Language:English
Published: Elsevier 2008-05-01
Series:Journal of Lipid Research
Subjects:
C24:1-sphingomyelin
LC-MS/MS
detergent-soluble fractions
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752042591X

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