Nonsteroidal anti-inflammatory drugs as the first step in treating musculoskeletal pain

• Main Authors: Andrei Evgenyevich Karateev, A. S. Misiyuk
• Format: Article
• Language: Russian
• Published: IMA-PRESS LLC 2015-09-01
• Series: Современная ревматология
• Subjects: nonsteroidal antiinflammatory drugs; musculoskeletal pain; pathogenesis; analgesic therapy; aceclofenac
• Online Access: https://mrj.ima-press.net/mrj/article/view/641

Pain control is a fundamental task in the management of patients with locomotor diseases. Analgesic therapy holds the most important position in treating common diseases, such as osteoarthritis, nonspecific spinal pain, and rheumatic diseases of juxtaarticular soft tissues. Pain development and chronization in these conditions are determined by a uniform pathogenetic mechanism, the key component of which should be considered to be inflammation. This necessitates the use of antiinflammatory drugs, first of all, nonsteroidal antiinflammatory drugs (NSAIDs). When the latter are used, the risk of their adverse reactions should be necessarily taken into account and the choice of a specific drug should be based on an efficacy-safety ratio. Aceclofenac may be legally regarded as one of the most balanced NSAIDs in this respect. The paper reviews the data available in the literature on the use of this drug, including the largest clinical and epidemiological studies.