Rapid and sensitive analysis of cyclobenzaprine by LC–MS/MS: Application to a pharmacokinetic study of cyclobenzaprine in dog

Rapid and sensitive analysis of cyclobenzaprine by LC–MS/MS: Application to a pharmacokinetic study of cyclobenzaprine in dog

A rapid and sensitive liquid chromatography–tandem mass spectrometry method was developed and validated for the quantification of cyclobenzaprine in dog plasma. After extracted with organic solvent, post-treatment samples were separated on an Agela C18 column interfaced with a triple quadrupole tand...

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Bibliographic Details
Main Authors: Wenhong Yu, Xiaojing Yang, Wenwen Sui, Haiyan Xu, Xinyi Luan, Xiangjun Wang, Yi Jin, Bo Yuan
Format: Article
Language:English
Published: Elsevier 2014-04-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Cyclobenzaprine
LC–MS/MS
Pharmacokinetic
Plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087614000087

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http://www.sciencedirect.com/science/article/pii/S1818087614000087

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