Resilience and Vulnerability to Pain and Inflammation in the Hippocampus

Increasing evidence demonstrates the importance of hippocampal neurogenesis, a fundamental mechanism of neuroplasticity associated with cognition and emotion, in correlation to neurodegenerative and psychiatric disorders. Neuropsychiatric disorders are often a result of chronic stress or pain follow...

Full description

Bibliographic Details
Main Authors:	Verica Vasic, Mirko H. H. Schmidt
Format:	Article
Language:	English
Published:	MDPI AG 2017-03-01
Series:	International Journal of Molecular Sciences
Subjects:	neurogenesis resilience inflammation pain neuropsychiatric disorders
Online Access:	http://www.mdpi.com/1422-0067/18/4/739

id	doaj-652b59b45d054d14b2ea81d0a4bcffb8
record_format	Article
spelling	doaj-652b59b45d054d14b2ea81d0a4bcffb82020-11-24T23:18:56ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-03-0118473910.3390/ijms18040739ijms18040739Resilience and Vulnerability to Pain and Inflammation in the HippocampusVerica Vasic0Mirko H. H. Schmidt1Molecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn<sup>2</sup>), Johannes Gutenberg University, School of Medicine, Mainz 55131, GermanyMolecular Signal Transduction Laboratories, Institute for Microscopic Anatomy and Neurobiology, Focus Program Translational Neuroscience (FTN), Rhine Main Neuroscience Network (rmn<sup>2</sup>), Johannes Gutenberg University, School of Medicine, Mainz 55131, GermanyIncreasing evidence demonstrates the importance of hippocampal neurogenesis, a fundamental mechanism of neuroplasticity associated with cognition and emotion, in correlation to neurodegenerative and psychiatric disorders. Neuropsychiatric disorders are often a result of chronic stress or pain followed by inflammation; all these conditions manifest cognitive deficits and impairments in neurogenesis. However, while some individuals are more susceptible to stress, others are able to adapt to new environments via mechanisms of resilience. In light of this emerging field and based on extensive research, the role of neurogenesis is summarized and presented as a potentially powerful therapeutic tool.http://www.mdpi.com/1422-0067/18/4/739neurogenesisresilienceinflammationpainneuropsychiatric disorders
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Verica Vasic Mirko H. H. Schmidt
spellingShingle	Verica Vasic Mirko H. H. Schmidt Resilience and Vulnerability to Pain and Inflammation in the Hippocampus International Journal of Molecular Sciences neurogenesis resilience inflammation pain neuropsychiatric disorders
author_facet	Verica Vasic Mirko H. H. Schmidt
author_sort	Verica Vasic
title	Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
title_short	Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
title_full	Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
title_fullStr	Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
title_full_unstemmed	Resilience and Vulnerability to Pain and Inflammation in the Hippocampus
title_sort	resilience and vulnerability to pain and inflammation in the hippocampus
publisher	MDPI AG
series	International Journal of Molecular Sciences
issn	1422-0067
publishDate	2017-03-01
description	Increasing evidence demonstrates the importance of hippocampal neurogenesis, a fundamental mechanism of neuroplasticity associated with cognition and emotion, in correlation to neurodegenerative and psychiatric disorders. Neuropsychiatric disorders are often a result of chronic stress or pain followed by inflammation; all these conditions manifest cognitive deficits and impairments in neurogenesis. However, while some individuals are more susceptible to stress, others are able to adapt to new environments via mechanisms of resilience. In light of this emerging field and based on extensive research, the role of neurogenesis is summarized and presented as a potentially powerful therapeutic tool.
topic	neurogenesis resilience inflammation pain neuropsychiatric disorders
url	http://www.mdpi.com/1422-0067/18/4/739
work_keys_str_mv	AT vericavasic resilienceandvulnerabilitytopainandinflammationinthehippocampus AT mirkohhschmidt resilienceandvulnerabilitytopainandinflammationinthehippocampus
_version_	1725579301170970624

Resilience and Vulnerability to Pain and Inflammation in the Hippocampus

Similar Items