Association between butyrylcholinesterase activity and low-grade systemic inflammation

Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and...

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Main Authors: Natalia Lampón, Esperanza F. Hermida-Cadahia, Alberto Riveiro, J. Carlos Tutor
Format: Article
Language:English
Published: Elsevier 2012-05-01
Series:Annals of Hepatology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268119309329
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spelling doaj-6508b49142924d5a8ae4a3a912dcc3272021-06-09T05:52:44ZengElsevierAnnals of Hepatology1665-26812012-05-01113356363Association between butyrylcholinesterase activity and low-grade systemic inflammationNatalia Lampón0Esperanza F. Hermida-Cadahia1Alberto Riveiro2J. Carlos Tutor3Unidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, SpainUnidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, SpainSección de Bioquímica, Laboratorio Central, Hospital Clínico Universitario, 15706 Santiago de Compostela, SpainUnidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, Spain; Correspondence and reprint request:Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and the aim of our study was to evaluate its association with low-grade systemic inflammation.Material and methods. A total of 4,077 patients clinically managed in the Cardiology, Hypertension, and Digestive Medicine Units were included in our study. Three subclinical chronic inflammatory degrees were established in accordance with the high-sensitivity C-reactive protein (hsCRP) concentrations proposed, for low (< 1 mg/L), average (1-3 mg/L), and high (> 3-10 mg/L) cardiovascular disease risk estimation.Results. In male patients with subclinical chronic inflammation and hsCRP concentrations < 1 mg/L, a significant positive correlation was observed between BChE and hsCRP (p < 0.02); however, for hsCRP concentrations > 3 mg/L, the correlation between these variables in both sexes becomes significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L). In all cases significant positive correlations were obtained between the BChE activities and albumin concentrations (p < 0.001).Conclusions. The liver production of BChE and albumin occurs in a coupled fashion, and these biochemical variables may be considered as negative inflammatory reactants, whose serum levels are inversely associated with the increasing degree of subclinical inflammation.http://www.sciencedirect.com/science/article/pii/S1665268119309329ButyrylcholinesteraseAlbuminHigh-sensitivity C-reactive proteinProcalcitoninLow-grade systemic inflammation
collection DOAJ
language English
format Article
sources DOAJ
author Natalia Lampón
Esperanza F. Hermida-Cadahia
Alberto Riveiro
J. Carlos Tutor
spellingShingle Natalia Lampón
Esperanza F. Hermida-Cadahia
Alberto Riveiro
J. Carlos Tutor
Association between butyrylcholinesterase activity and low-grade systemic inflammation
Annals of Hepatology
Butyrylcholinesterase
Albumin
High-sensitivity C-reactive protein
Procalcitonin
Low-grade systemic inflammation
author_facet Natalia Lampón
Esperanza F. Hermida-Cadahia
Alberto Riveiro
J. Carlos Tutor
author_sort Natalia Lampón
title Association between butyrylcholinesterase activity and low-grade systemic inflammation
title_short Association between butyrylcholinesterase activity and low-grade systemic inflammation
title_full Association between butyrylcholinesterase activity and low-grade systemic inflammation
title_fullStr Association between butyrylcholinesterase activity and low-grade systemic inflammation
title_full_unstemmed Association between butyrylcholinesterase activity and low-grade systemic inflammation
title_sort association between butyrylcholinesterase activity and low-grade systemic inflammation
publisher Elsevier
series Annals of Hepatology
issn 1665-2681
publishDate 2012-05-01
description Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and the aim of our study was to evaluate its association with low-grade systemic inflammation.Material and methods. A total of 4,077 patients clinically managed in the Cardiology, Hypertension, and Digestive Medicine Units were included in our study. Three subclinical chronic inflammatory degrees were established in accordance with the high-sensitivity C-reactive protein (hsCRP) concentrations proposed, for low (< 1 mg/L), average (1-3 mg/L), and high (> 3-10 mg/L) cardiovascular disease risk estimation.Results. In male patients with subclinical chronic inflammation and hsCRP concentrations < 1 mg/L, a significant positive correlation was observed between BChE and hsCRP (p < 0.02); however, for hsCRP concentrations > 3 mg/L, the correlation between these variables in both sexes becomes significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L). In all cases significant positive correlations were obtained between the BChE activities and albumin concentrations (p < 0.001).Conclusions. The liver production of BChE and albumin occurs in a coupled fashion, and these biochemical variables may be considered as negative inflammatory reactants, whose serum levels are inversely associated with the increasing degree of subclinical inflammation.
topic Butyrylcholinesterase
Albumin
High-sensitivity C-reactive protein
Procalcitonin
Low-grade systemic inflammation
url http://www.sciencedirect.com/science/article/pii/S1665268119309329
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