Association between butyrylcholinesterase activity and low-grade systemic inflammation
Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2012-05-01
|
Series: | Annals of Hepatology |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1665268119309329 |
id |
doaj-6508b49142924d5a8ae4a3a912dcc327 |
---|---|
record_format |
Article |
spelling |
doaj-6508b49142924d5a8ae4a3a912dcc3272021-06-09T05:52:44ZengElsevierAnnals of Hepatology1665-26812012-05-01113356363Association between butyrylcholinesterase activity and low-grade systemic inflammationNatalia Lampón0Esperanza F. Hermida-Cadahia1Alberto Riveiro2J. Carlos Tutor3Unidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, SpainUnidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, SpainSección de Bioquímica, Laboratorio Central, Hospital Clínico Universitario, 15706 Santiago de Compostela, SpainUnidad Monitorización de Fármacos, Laboratorio Central, Hospital Clínico Universitario, Instituto de Investigación Sanitaria (IDIS), 15706 Santiago de Compostela, Spain; Correspondence and reprint request:Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and the aim of our study was to evaluate its association with low-grade systemic inflammation.Material and methods. A total of 4,077 patients clinically managed in the Cardiology, Hypertension, and Digestive Medicine Units were included in our study. Three subclinical chronic inflammatory degrees were established in accordance with the high-sensitivity C-reactive protein (hsCRP) concentrations proposed, for low (< 1 mg/L), average (1-3 mg/L), and high (> 3-10 mg/L) cardiovascular disease risk estimation.Results. In male patients with subclinical chronic inflammation and hsCRP concentrations < 1 mg/L, a significant positive correlation was observed between BChE and hsCRP (p < 0.02); however, for hsCRP concentrations > 3 mg/L, the correlation between these variables in both sexes becomes significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L). In all cases significant positive correlations were obtained between the BChE activities and albumin concentrations (p < 0.001).Conclusions. The liver production of BChE and albumin occurs in a coupled fashion, and these biochemical variables may be considered as negative inflammatory reactants, whose serum levels are inversely associated with the increasing degree of subclinical inflammation.http://www.sciencedirect.com/science/article/pii/S1665268119309329ButyrylcholinesteraseAlbuminHigh-sensitivity C-reactive proteinProcalcitoninLow-grade systemic inflammation |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Natalia Lampón Esperanza F. Hermida-Cadahia Alberto Riveiro J. Carlos Tutor |
spellingShingle |
Natalia Lampón Esperanza F. Hermida-Cadahia Alberto Riveiro J. Carlos Tutor Association between butyrylcholinesterase activity and low-grade systemic inflammation Annals of Hepatology Butyrylcholinesterase Albumin High-sensitivity C-reactive protein Procalcitonin Low-grade systemic inflammation |
author_facet |
Natalia Lampón Esperanza F. Hermida-Cadahia Alberto Riveiro J. Carlos Tutor |
author_sort |
Natalia Lampón |
title |
Association between butyrylcholinesterase activity and low-grade systemic inflammation |
title_short |
Association between butyrylcholinesterase activity and low-grade systemic inflammation |
title_full |
Association between butyrylcholinesterase activity and low-grade systemic inflammation |
title_fullStr |
Association between butyrylcholinesterase activity and low-grade systemic inflammation |
title_full_unstemmed |
Association between butyrylcholinesterase activity and low-grade systemic inflammation |
title_sort |
association between butyrylcholinesterase activity and low-grade systemic inflammation |
publisher |
Elsevier |
series |
Annals of Hepatology |
issn |
1665-2681 |
publishDate |
2012-05-01 |
description |
Background. Pro-inflammatory cytokine production is directly inhibited by acetylcholine (ACh), and a relationship between total circulating ACh hydrolytic capacity and inflammatory reactions has been previously reported. Butyrylcholinesterase (BChE) is the major ACh hydrolyzing enzyme in plasma, and the aim of our study was to evaluate its association with low-grade systemic inflammation.Material and methods. A total of 4,077 patients clinically managed in the Cardiology, Hypertension, and Digestive Medicine Units were included in our study. Three subclinical chronic inflammatory degrees were established in accordance with the high-sensitivity C-reactive protein (hsCRP) concentrations proposed, for low (< 1 mg/L), average (1-3 mg/L), and high (> 3-10 mg/L) cardiovascular disease risk estimation.Results. In male patients with subclinical chronic inflammation and hsCRP concentrations < 1 mg/L, a significant positive correlation was observed between BChE and hsCRP (p < 0.02); however, for hsCRP concentrations > 3 mg/L, the correlation between these variables in both sexes becomes significantly negative (p < 0.001), as in patients with acute inflammation (hsCRP > 10 mg/L). In all cases significant positive correlations were obtained between the BChE activities and albumin concentrations (p < 0.001).Conclusions. The liver production of BChE and albumin occurs in a coupled fashion, and these biochemical variables may be considered as negative inflammatory reactants, whose serum levels are inversely associated with the increasing degree of subclinical inflammation. |
topic |
Butyrylcholinesterase Albumin High-sensitivity C-reactive protein Procalcitonin Low-grade systemic inflammation |
url |
http://www.sciencedirect.com/science/article/pii/S1665268119309329 |
work_keys_str_mv |
AT natalialampon associationbetweenbutyrylcholinesteraseactivityandlowgradesystemicinflammation AT esperanzafhermidacadahia associationbetweenbutyrylcholinesteraseactivityandlowgradesystemicinflammation AT albertoriveiro associationbetweenbutyrylcholinesteraseactivityandlowgradesystemicinflammation AT jcarlostutor associationbetweenbutyrylcholinesteraseactivityandlowgradesystemicinflammation |
_version_ |
1721388939940462592 |