| Summary: | Idiopathic membranous nephropathy is a common primary glomerular disease. Recently, it has
been found that the progression and prognosis of glomerular diseases are not only related to the
glomeruli itself, but also to the severity of renal tubular injury. Although blood creatinine and
urinary protein are recognized biomarkers, they appear late, are insensitive, lack specificity,
and are difficult to respond to IMN conditions in a timely and accurate manner. Markers such
as N-acetyl-β-D-glucosaminidase, kidney injury molecule 1, neutrophil gelatinase-associated
lipoprotein in urine can dynamically reflect the progress of kidney injury in the early stage, and
are detected as noninvasive, so It has been applied in IMN, but such research is lacking, and
the scope needs to be further expanded and discussed in depth.
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