Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression

Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression

<p>Abstract</p> <p>Background</p> <p><it>In vivo </it>studies on HIV-1 pathogenesis and testing of antiviral strategies have been hampered by the lack of an immunocompetent small animal model that is highly susceptible to HIV-1 infection. Since native rodent...

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Bibliographic Details
Main Authors: Hermann Volker, Tervo Hanna-Mari, Allespach Ina, Michel Nico, Goffinet Christine, Kräusslich Hans-Georg, Greene Warner C, Keppler Oliver T
Format: Article
Language:English
Published: BMC 2007-07-01
Series:Retrovirology
Online Access:http://www.retrovirology.com/content/4/1/53

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