The Effect of Botulinum Neurotoxin Serotype a Heavy Chain on the Growth Related Proteins and Neurite Outgrowth after Spinal Cord Injury in Rats

The Effect of Botulinum Neurotoxin Serotype a Heavy Chain on the Growth Related Proteins and Neurite Outgrowth after Spinal Cord Injury in Rats

(1) Background: The botulinum toxin A (BoNT-A) heavy chain (HC) can stimulate the growth of primary motor neurites. (2) Methods: A recombinant BoNT/A HC was injected locally plus interval intrathecal catheter of BoNT/A HC to rats with ipsilateral semi-dissociated lumbar spinal cord injuries (SCIs)....

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Bibliographic Details
Main Authors: Ya-Fang Wang, Fu Liu, Jing Lan, Juan Bai, Xia-Qing Li
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Toxins
Subjects:
botulinum neurotoxins
botulinum neurotoxin serotype A
heavy chain
botulinum neurotoxin serotype a heavy chain (BoNT/A HC)
spinal cord injury (SCI)
nerve regeneration
growth associated protein 43 (GAP-43)
superior cervical ganglion 10 (SCG10)
neuronal processes
neural regeneration
Online Access:http://www.mdpi.com/2072-6651/10/2/66

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