Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study

Macromolecular confinement of therapeutic protein in polymeric particles for controlled release: insulin as a case study

ABSTRACT Sustained release systems for therapeutic proteins have been widely studied targeting to improve the action of these drugs. Molecular entrapping of proteins is particularly challenging due to their conformational instability. We have developed a micro-structured poly-epsilon-caprolactone (P...

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Bibliographic Details
Main Authors: Luiz Henrique Guerreiro, Daniel da Silva, Wendell Girard-Dias, Camile Moreira Mascarenhas, Kildare Miranda, Mauro Sola-Penna, Eduardo Ricci Júnior, Luís Mauricio Trambaioli da Rocha e Lima
Format: Article
Language:English
Published: Universidade de São Paulo 2017-06-01
Series:Brazilian Journal of Pharmaceutical Sciences
Subjects:
Human insulin/study
Microparticles
Poly-ε-caprolactone
Therapeutic proteins/study/action
Proteins/molecular entrapping
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200622&lng=en&tlng=en

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502017000200622&lng=en&tlng=en

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