Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish
The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05105-8 |
| id |
doaj-64eea95ed93b4eecac80df588701028f |
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| record_format |
Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Shaoyang Zhao Jianhong Xia Xiuhua Wu Leilei Zhang Pengtao Wang Haiyun Wang Heying Li Xiaoshan Wang Yan Chen Jean Agnetti Yinxiong Li Duanqing Pei Xiaodong Shu |
| spellingShingle |
Shaoyang Zhao Jianhong Xia Xiuhua Wu Leilei Zhang Pengtao Wang Haiyun Wang Heying Li Xiaoshan Wang Yan Chen Jean Agnetti Yinxiong Li Duanqing Pei Xiaodong Shu Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish Nature Communications |
| author_facet |
Shaoyang Zhao Jianhong Xia Xiuhua Wu Leilei Zhang Pengtao Wang Haiyun Wang Heying Li Xiaoshan Wang Yan Chen Jean Agnetti Yinxiong Li Duanqing Pei Xiaodong Shu |
| author_sort |
Shaoyang Zhao |
| title |
Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish |
| title_short |
Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish |
| title_full |
Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish |
| title_fullStr |
Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish |
| title_full_unstemmed |
Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafish |
| title_sort |
deficiency in class iii pi3-kinase confers postnatal lethality with ibd-like features in zebrafish |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-07-01 |
| description |
The functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins. |
| url |
https://doi.org/10.1038/s41467-018-05105-8 |
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doaj-64eea95ed93b4eecac80df588701028f2021-05-11T09:55:02ZengNature Publishing GroupNature Communications2041-17232018-07-019111310.1038/s41467-018-05105-8Deficiency in class III PI3-kinase confers postnatal lethality with IBD-like features in zebrafishShaoyang Zhao0Jianhong Xia1Xiuhua Wu2Leilei Zhang3Pengtao Wang4Haiyun Wang5Heying Li6Xiaoshan Wang7Yan Chen8Jean Agnetti9Yinxiong Li10Duanqing Pei11Xiaodong Shu12School of Life Sciences, University of Science and Technology of ChinaCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesCAS Key Laboratory of Regenerative Biology, Guangzhou Institute of Biomedicine and Health-Guangzhou Medical University Joint School of Biological Sciences, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of SciencesThe functions of the class III PI3-kinase (PIK3C3) in gut homeostasis and innate immunity are poorly understood. Here the authors show that PIK3C3-deficient zebrafishes develop intestinal injury and inflammation due to mislocalization of cell junction proteins.https://doi.org/10.1038/s41467-018-05105-8 |