Development of a Fluorescent Assay to Search New Drugs Using Stable tdTomato-Leishmania, and the Selection of Galangin as a Candidate With Anti-Leishmanial Activity

Development of a Fluorescent Assay to Search New Drugs Using Stable tdTomato-Leishmania, and the Selection of Galangin as a Candidate With Anti-Leishmanial Activity

Antimonials continue to be considered the first-line treatment for leishmaniases, but its use entails a wide range of side effects and serious reactions. The search of new drugs requires the development of methods more sensitive and faster than the conventional ones. We developed and validated a flu...

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Bibliographic Details
Main Authors: María Fernanda García-Bustos, Agustín Moya Álvarez, Cecilia Pérez Brandan, Cecilia Parodi, Andrea Mabel Sosa, Valeria Carolina Buttazzoni Zuñiga, Oscar Marcelo Pastrana, Paula Manghera, Pablo Alejandro Peñalva, Jorge Diego Marco, Paola Andrea Barroso
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
tdTomato
L. (L.) amazonensis
flavonoids
galangin
fluorescence
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.666746/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.666746/full

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