Spontaneous Remission and Concomitant Progression in a Patient with DLBCL

• Main Authors: Eun Ji Han, Jihyun Kim, Suk Young Park, Joo Hyun O
• Format: Article
• Language: English
• Published: MDPI AG 2020-11-01
• Series: Diagnostics
• Subjects: diffuse large B-cell lymphoma; spontaneous remission; FDG; PET/CT
• Online Access: https://www.mdpi.com/2075-4418/10/11/950

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Although DLBCL can be cured in more than half of all patients, up to 50% of patients become refractory to initial treatment or relapse after complete remission. We present a case of complete spontaneous remission of some tumors and concomitant newly developed tumors observed in a patient with relapsed DLBCL. Spontaneous remission of lymphoma without treatment is a rare phenomenon and can occur at baseline as well as in relapsed DLBCL. However, most patients who initially experience spontaneous remission later develop relapse. Thus, careful follow-up is required, and fluorine-18-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) allows monitoring of multiple lesions.