Iron-responsive miR-485-3p regulates cellular iron homeostasis by targeting ferroportin.
Ferroportin (FPN) is the only known cellular iron exporter in mammalian cells and plays a critical role in the maintenance of both cellular and systemic iron balance. During iron deprivation, the translation of FPN is repressed by iron regulatory proteins (IRPs), which bind to the 5' untranslat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-04-01
|
| Series: | PLoS Genetics |
| Online Access: | http://europepmc.org/articles/PMC3616902?pdf=render |