Consensus-Based Pharmacophore Mapping for New Set of <i>N</i>-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides

Consensus-Based Pharmacophore Mapping for New Set of <i>N</i>-(disubstituted-phenyl)-3-hydroxyl-naphthalene-2-carboxamides

A series of twenty-two novel <i>N</i>-(disubstituted-phenyl)-3-hydroxynaphthalene- 2-carboxamide derivatives was synthesized and characterized as potential antimicrobial agents. <i>N</i>-[3,5-bis(trifluoromethyl)phenyl]- and <i>N</i>-[2-chloro-5-(trifluoromethyl)p...

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Bibliographic Details
Main Authors: Andrzej Bak, Jiri Kos, Hana Michnova, Tomas Gonec, Sarka Pospisilova, Violetta Kozik, Alois Cizek, Adam Smolinski, Josef Jampilek
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
hydroxynaphthalenecarboxamides
lipophilicity
antistaphylococcal activity
antitubercular activity
MIC
MTT assay
Online Access:https://www.mdpi.com/1422-0067/21/18/6583

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