The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects

The Incoherent Fluctuation of Folate Pools and Differential Regulation of Folate Enzymes Prioritize Nucleotide Supply in the Zebrafish Model Displaying Folate Deficiency-Induced Microphthalmia and Visual Defects

ObjectiveCongenital eye diseases are multi-factorial and usually cannot be cured. Therefore, proper preventive strategy and understanding the pathomechanism underlying these diseases become important. Deficiency in folate, a water-soluble vitamin B, has been associated with microphthalmia, a congeni...

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Bibliographic Details
Main Authors: Tsun-Hsien Hsiao, Gang-Hui Lee, Yi-Sheng Chang, Bing-Hung Chen, Tzu-Fun Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
folate
one-carbon metabolism
eye diseases
zebrafish
microphthalmia
mthfd1L
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.702969/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2021.702969/full

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