Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring

Maternal High-Protein and Low-Protein Diets Perturb Hypothalamus and Liver Transcriptome and Metabolic Homeostasis in Adult Mouse Offspring

Early life nutritional imbalances are risk factors for metabolic dysfunctions in adulthood, but the long term effects of perinatal exposure to high versus low protein diets are not completely understood. We exposed C57BL/6J offspring to a high protein/low carbohydrate (HP/LC) or low protein/high car...

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Bibliographic Details
Main Authors: Lisa J. Martin, Qingying Meng, Montgomery Blencowe, Sandrine Lagarrigue, Sheila Xiao, Calvin Pan, Julian Wier, William C. Temple, Sherin U. Devaskar, Aldons J. Lusis, Xia Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Genetics
Subjects:
maternal diet
high protein
low protein
gene expression
metabolic dysfunction
glucose intolerance
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2018.00642/full

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