The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

The demethylase inhibitor GSK-J4 limits inflammatory colitis by promoting de novo synthesis of retinoic acid in dendritic cells

Abstract Dendritic cells (DCs) promote T-cell mediated tolerance to self-antigens and induce inflammation to innocuous-antigens. This dual potential makes DCs fundamental players in inflammatory disorders. Evidence from inflammatory colitis mouse models and inflammatory bowel diseases (IBD) patients...

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Bibliographic Details
Main Authors: Cristian Doñas, Jocelyn Neira, Francisco Osorio-Barrios, Macarena Carrasco, Dominique Fernández, Carolina Prado, Alejandra Loyola, Rodrigo Pacheco, Mario Rosemblatt
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-79122-3

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https://doi.org/10.1038/s41598-020-79122-3

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