Control of mRNA Splicing by Intragenic RNA Activators of Stress Signaling: Potential Implications for Human Disease

Control of mRNA Splicing by Intragenic RNA Activators of Stress Signaling: Potential Implications for Human Disease

A critical step in the cellular stress response is transient activation of the RNA-dependent protein kinase PKR by double-helical RNA, resulting in down-regulation of protein synthesis through phosphorylation of the α chain of translation initiation factor eIF2, a major PKR substrate. However, intra...

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Bibliographic Details
Main Authors: Raymond Kaempfer, Lena Ilan, Smadar Cohen-Chalamish, Orli Turgeman, Lise Sarah Namer, Farhat Osman
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Genetics
Subjects:
mRNA splicing control
intragenic RNA activators of PKR
activation of PKR
eIF2α phosphorylation
PKR silencer elements
TNF-α gene
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2019.00464/full

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https://www.frontiersin.org/article/10.3389/fgene.2019.00464/full

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