Research progress on the intervening effects of active components of Chinese herbs on amyloid-beta-induced injury of neural cells

• Main Authors: Hang-Xuan Wu, Er-Wei Hao, Zheng-Cai Du, Jian-Feng Qin, Wei Wei, Xiang-Long Pan, Jin-Ling Xie, Xiao-Tao Hou, Jia-Gang Deng
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: World Journal of Traditional Chinese Medicine
• Subjects: Alzheimer's disease; amyloid-beta cascade reaction; monomer composition; traditional Chinese medicine; β-amyloid
• Online Access: http://www.wjtcm.net/article.asp?issn=2311-8571;year=2019;volume=5;issue=2;spage=122;epage=130;aulast=Wu

Alzheimer's disease is a common clinical central nervous system degenerative disease. From 1906, it has not yet been clearly revealed the pathogenesis, and there are no clinically safe and effective drugs. Amyloid-beta (Aβ) cascade reaction theory is currently recognized as the pathogenesis. Aβ deposition of neurotoxicity is an important part of the pathogenesis. There are Aβ-induced inflammation of the central nervous and oxidative stress-induced apoptosis induced by a variety of ways leading to neuronal dysfunction and death. This article summarizes the active ingredients of traditional Chinese medicine that has a protective effect on Aβ toxicity in recent years. Traditional Chinese medicine mainly through the antiapoptosis, antioxidation, and anti-inflammatory reduces Aβ production and deposition of Aβ on the protection of nerve cell injury.