Circulating Tumor DNA-Based Detection of Microsatellite Instability and Response to Immunotherapy in Pancreatic Cancer

Circulating Tumor DNA-Based Detection of Microsatellite Instability and Response to Immunotherapy in Pancreatic Cancer

Pancreatic cancer is an aggressive malignancy with poor survival. Research has indicated the association of few genetic aberrations with pancreatic cancer. The data regarding the prevalence of microsatellite instability in pancreatic cancer is diverse and controversial. However, it could be an actio...

Full description

Bibliographic Details
Main Authors:	Saivaishnavi Kamatham, Faisal Shahjehan, Pashtoon Murtaza Kasi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2020-02-01
Series:	Frontiers in Pharmacology
Subjects:	circulating tumor DNA microsatellite instability pancreatic cancer immunotherapy pembrolizumab
Online Access:	https://www.frontiersin.org/article/10.3389/fphar.2020.00023/full

Similar Items

Role of Circulating Tumor DNA in Gastrointestinal Cancers: Update From Abstracts and Sessions at ASCO 2018
by: Faisal Shahjehan, et al.
Published: (2019-05-01)

Pembrolizumab for a patient with metastatic castration‐resistant prostate cancer with microsatellite instability‐high
by: Motohiro Fujiwara, et al.
Published: (2020-03-01)

Successful pembrolizumab treatment of microsatellite instability‐high intrahepatic cholangiocarcinoma: A case report
by: Yuki Ikeda, et al.
Published: (2021-04-01)

Rapid Response to Pembrolizumab in a Chemo-Refractory Testicular Germ Cell Cancer with Microsatellite Instability-High
by: Kawai K, et al.
Published: (2021-09-01)

Detection of Microsatellite Instability via Circulating Tumor DNA and Response to Immunotherapy in Metastatic Castration-Resistant Prostate Cancer: A Case Series
by: Deepak Ravindranathan, et al.
Published: (2021-03-01)

Dramatic response to modified docetaxel, cisplatin, and fluorouracil chemotherapy after immunotherapy in a patient with refractory metastatic anal cancer
by: Faisal Shahjehan, et al.
Published: (2019-09-01)

Detection of Microsatellite Instability: State of the Art and Future Applications in Circulating Tumour DNA (ctDNA)
by: Pauline Gilson, et al.
Published: (2021-03-01)

Significance and implications of FDA approval of pembrolizumab for biomarker-defined disease
by: Michael M. Boyiadzis, et al.
Published: (2018-05-01)

Lynch syndrome-associated lung cancer: pitfalls of an immunotherapy-based treatment strategy in an unusual tumor type
by: Elena Maccaroni, et al.
Published: (2021-06-01)

Prospects of application of inhibitors of PD-1/PD-L1 checkpoints in malignant tumors of the stomach and esophagogastric junction
by: D. D. Sakaeva, et al.
Published: (2020-12-01)

Association between Microsatellite Instability Status and Peri-Operative Release of Circulating Tumour Cells in Colorectal Cancer
by: James W. T. Toh, et al.
Published: (2020-02-01)

Some aspects of immunotherapy in colon cancer
by: M. Yu. Fedyanin, et al.
Published: (2018-05-01)

High tumor mutational burden (TMB) identifies a microsatellite stable pancreatic cancer subset with prolonged survival and strong anti-tumor immunity
by: Andreou, A., et al.
Published: (2022)

Immune-Based Therapies and the Role of Microsatellite Instability in Pancreatic Cancer
by: Michele Ghidini, et al.
Published: (2021-12-01)

Success rate of microsatellite instability examination and complete response with pembrolizumab in biliary tract cancer
by: Yugo Kai, et al.
Published: (2021-06-01)

Clinical and morphological portrait of tumors with microsatellite instability
by: A. A. Musaelyan, et al.
Published: (2021-07-01)

Assessment of the Circulating Tumor Cells and Microsatellite Instability in Colorectal Cancer Patients: Prognostic and Diagnostic Value
by: Alsayed A, et al.
Published: (2021-03-01)

Artificial Intelligence for Histology-Based Detection of Microsatellite Instability and Prediction of Response to Immunotherapy in Colorectal Cancer
by: Lindsey A. Hildebrand, et al.
Published: (2021-01-01)

Efficacy of EUS-guided FNB using a Franseen needle for tissue acquisition and microsatellite instability evaluation in unresectable pancreatic lesions
by: Mitsuru Sugimoto, et al.
Published: (2020-11-01)

Pembrolizumab‐related pancreatitis with elevation of pancreatic tumour markers
by: Tamaki Kakuwa, et al.
Published: (2020-03-01)

Mismatch repair deficiency/microsatellite instability-high as a predictor for anti-PD-1/PD-L1 immunotherapy efficacy
by: Pengfei Zhao, et al.
Published: (2019-05-01)

Rapid regression of microsatellite instability-high/programmed cell death ligand 1-negative recurrent endometrial carcinoma by immune checkpoint blockade with pembrolizumab: A case report and literature review
by: Akihiro Takeda, et al.
Published: (2020-05-01)

Re‐exposure to immunotherapy in metastatic colon cancer: A case report
by: Tonje Riise Hamre, et al.
Published: (2021-06-01)

Immunotherapy, Inflammation and Colorectal Cancer
by: Charles Robert Lichtenstern, et al.
Published: (2020-03-01)

Clinical Aspects of Microsatellite Instability Testing in Colorectal Cancer
by: Mehrdad Zeinalian, et al.
Published: (2018-01-01)

Predictive Value of Metabolic Parameters Derived From 18F-FDG PET/CT for Microsatellite Instability in Patients With Colorectal Carcinoma
by: Hao Liu, et al.
Published: (2021-08-01)

Use of nivolumab for colon cancer with Lynch syndrome
by: G. A. Khakimov, et al.
Published: (2020-11-01)

Cell-free DNA profiling of metastatic prostate cancer reveals microsatellite instability, structural rearrangements and clonal hematopoiesis
by: Markus Mayrhofer, et al.
Published: (2018-11-01)

Sensitive detection of microsatellite instability in tissues and liquid biopsies: Recent developments and updates
by: Fangyan Yu, et al.
Published: (2021-01-01)

ARID1A genomic alterations driving microsatellite instability through somatic MLH1 methylation with response to immunotherapy in metastatic lung adenocarcinoma: a case report
by: Mercedes Durán, et al.
Published: (2021-02-01)

Immune Checkpoint Inhibition in Metastatic Colorectal Cancer Harboring Microsatellite Instability or Mismatch Repair Deficiency
by: Romain Cohen, et al.
Published: (2021-03-01)

Are Molecular Alterations Linked to Genetic Instability Worth to Be Included as Biomarkers for Directing or Excluding Melanoma Patients to Immunotherapy?
by: Giuseppe Palmieri, et al.
Published: (2021-05-01)

Population bias in somatic measurement of microsatellite instability status
by: Michelle Saul, et al.
Published: (2020-09-01)

Real-world application of tumor mutational burden-high (TMB-high) and microsatellite instability (MSI) confirms their utility as immunotherapy biomarkers
by: Chan, N., et al.
Published: (2022)

Role of microsatellite instability in colon cancer
by: M. Yu. Fedyanin, et al.
Published: (2015-02-01)

Microsatellite instability in medullary carcinoma of the colon
by: Mario Martinotti, et al.
Published: (2017-03-01)

Endometrial cancer and microsatellite instability status
by: Kanopiene Daiva, et al.
Published: (2014-11-01)

ctDNA Clearance and Radiographic Resolution of Disease in Response to Dual Checkpoint Inhibition in Metastatic Microsatellite Stable Colorectal Cancer with a High Tumor Mutation Burden
by: Charles J. Schneider, et al.
Published: (2021-06-01)

Management of Non-Colorectal Digestive Cancers with Microsatellite Instability
by: Mojun Zhu, et al.
Published: (2021-02-01)

Impact of microsatellite instability on survival of endometrial cancer patients
by: Daiva Kanopienė, et al.
Published: (2014-01-01)

Cannot write session to /tmp/vufind_sessions/sess_cvl9f6o2sbpa0bnkdtkkfgr2m0