Concepts of extracellular matrix remodelling in tumour progression and metastasis

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Tumors are more than cancer cells — the extracellular matrix is a protein structure that organizes all tissues and is altered in cancer. Here, the authors review recent progress in understanding how the cancer cells and tumor-associated stroma cells remodel the extracellular matrix to drive tumor gr...

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Main Authors: Juliane Winkler, Abisola Abisoye-Ogunniyan, Kevin J. Metcalf, Zena Werb
Format: Article
Language:English
Published: Nature Publishing Group 2020-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18794-x
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spelling doaj-64c57786027e46eeaaca470666599a222021-10-10T11:46:52ZengNature Publishing GroupNature Communications2041-17232020-10-0111111910.1038/s41467-020-18794-xConcepts of extracellular matrix remodelling in tumour progression and metastasisJuliane Winkler0Abisola Abisoye-Ogunniyan1Kevin J. Metcalf2Zena Werb3Department of Anatomy, Helen Diller Family Comprehensive Cancer Center, University of CaliforniaDepartment of Anatomy, Helen Diller Family Comprehensive Cancer Center, University of CaliforniaDepartment of Anatomy, Helen Diller Family Comprehensive Cancer Center, University of CaliforniaDepartment of Anatomy, Helen Diller Family Comprehensive Cancer Center, University of CaliforniaTumors are more than cancer cells — the extracellular matrix is a protein structure that organizes all tissues and is altered in cancer. Here, the authors review recent progress in understanding how the cancer cells and tumor-associated stroma cells remodel the extracellular matrix to drive tumor growth and metastasis.https://doi.org/10.1038/s41467-020-18794-x
collection DOAJ
language English
format Article
sources DOAJ
author Juliane Winkler
Abisola Abisoye-Ogunniyan
Kevin J. Metcalf
Zena Werb
spellingShingle Juliane Winkler
Abisola Abisoye-Ogunniyan
Kevin J. Metcalf
Zena Werb
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Nature Communications
author_facet Juliane Winkler
Abisola Abisoye-Ogunniyan
Kevin J. Metcalf
Zena Werb
author_sort Juliane Winkler
title Concepts of extracellular matrix remodelling in tumour progression and metastasis
title_short Concepts of extracellular matrix remodelling in tumour progression and metastasis
title_full Concepts of extracellular matrix remodelling in tumour progression and metastasis
title_fullStr Concepts of extracellular matrix remodelling in tumour progression and metastasis
title_full_unstemmed Concepts of extracellular matrix remodelling in tumour progression and metastasis
title_sort concepts of extracellular matrix remodelling in tumour progression and metastasis
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-10-01
description Tumors are more than cancer cells — the extracellular matrix is a protein structure that organizes all tissues and is altered in cancer. Here, the authors review recent progress in understanding how the cancer cells and tumor-associated stroma cells remodel the extracellular matrix to drive tumor growth and metastasis.
url https://doi.org/10.1038/s41467-020-18794-x
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AT abisolaabisoyeogunniyan conceptsofextracellularmatrixremodellingintumourprogressionandmetastasis
AT kevinjmetcalf conceptsofextracellularmatrixremodellingintumourprogressionandmetastasis
AT zenawerb conceptsofextracellularmatrixremodellingintumourprogressionandmetastasis
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