Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

Risk of Bias in Reports of In Vivo Research: A Focus for Improvement.

The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact,...

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Bibliographic Details
Main Authors: Malcolm R Macleod, Aaron Lawson McLean, Aikaterini Kyriakopoulou, Stylianos Serghiou, Arno de Wilde, Nicki Sherratt, Theo Hirst, Rachel Hemblade, Zsanett Bahor, Cristina Nunes-Fonseca, Aparna Potluru, Andrew Thomson, Julija Baginskaite, Kieren Egan, Hanna Vesterinen, Gillian L Currie, Leonid Churilov, David W Howells, Emily S Sena
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-10-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.1002273
Description
Summary:The reliability of experimental findings depends on the rigour of experimental design. Here we show limited reporting of measures to reduce the risk of bias in a random sample of life sciences publications, significantly lower reporting of randomisation in work published in journals of high impact, and very limited reporting of measures to reduce the risk of bias in publications from leading United Kingdom institutions. Ascertainment of differences between institutions might serve both as a measure of research quality and as a tool for institutional efforts to improve research quality.
ISSN:1544-9173
1545-7885

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