Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in miceResearch in context

Targeting hepatic miR-221/222 for therapeutic intervention of nonalcoholic steatohepatitis in miceResearch in context

Background: Effective targeting therapies for common chronic liver disease nonalcoholic steatohepatitis (NASH) are in urgent need. MicroRNA-targeted therapeutics would be potentially an effective treatment strategy of hepatic diseases. Here we investigated the functional role of miR-221/222 and the...

Full description

Bibliographic Details
Main Authors:	Xiuli Jiang, Lei Jiang, Aijing Shan, Yutong Su, Yulong Cheng, Dalong Song, He Ji, Guang Ning, Weiqing Wang, Yanan Cao
Format:	Article
Language:	English
Published:	Elsevier 2018-11-01
Series:	EBioMedicine
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352396418304080

Similar Items

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma
by: Zhang Chun-Zhi, et al.
Published: (2010-09-01)

Role of miR-221/222 in Tumor Development and the Underlying Mechanism
by: Qian Song, et al.
Published: (2019-01-01)

Human miR-221/222 in Physiological and Atherosclerotic Vascular Remodeling
by: Dmitry A. Chistiakov, et al.
Published: (2015-01-01)

Roles of Notch signaling in the control of miR-221/222 expression
by: Yuan-Fei Hsu, et al.
Published: (2012)

Influence of miR-221/222 on cardiomyocyte calcium handling and function
by: Maria Knyrim, et al.
Published: (2021-08-01)

Expression of miR-221/222 is affected by Triclosan in MCF-7 cells
by: Keivan Mobini, et al.
Published: (2019-09-01)

MiR-221/222 target the DNA methyltransferase MGMT in glioma cells.
by: Cristina Quintavalle, et al.
Published: (2013-01-01)

EGFR Signaling Pathway and Related-miRNAs In Age-related Diseases: The Example of miR-221 and miR-222
by: Ana L Teixeira, et al.
Published: (2012-12-01)

The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice.
by: Neri Mercatelli, et al.
Published: (2008-01-01)

Effect of miR-146 targeted HDMCP up-regulation in the pathogenesis of nonalcoholic steatohepatitis.
by: Xi Jin, et al.
Published: (2017-01-01)

Expression of miR⁃21, miR⁃221, and miR⁃222 in exosomes of CAL27 tongue squamous cell carcinoma cells
by: HUANG Wenxi, et al.
Published: (2018-04-01)

High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma
by: Zhang Chunzhi, et al.
Published: (2012-06-01)

Prognostic Role of miR-221 and miR-222 Expression in Cancer Patients: A Systematic Review and Meta-Analysis
by: Gloria Ravegnini, et al.
Published: (2019-07-01)

miR-182-5p Attenuates High-Fat -Diet-Induced Nonalcoholic Steatohepatitis in Mice
by: Qionghe Liang, et al.
Published: (2019-01-01)

Inhibition of miR-221/222 Expression in Hepatocellular Carcinoma via Baculovirus-Mediated CRISPRi System
by: Lin, Yi-Chun, et al.
Published: (2017)

HMGB1-Induced Cross Talk between PTEN and miRs 221/222 in Thyroid Cancer
by: S. Mardente, et al.
Published: (2015-01-01)

Expression and Change of miRs 145, 221 and 222 in Hypertensive Subjects Treated with Enalapril, Losartan or Olmesartan
by: Giuseppe Mandraffino, et al.
Published: (2021-07-01)

Oncogenic role of miRNA-221/222 in breast cancer
by: I Wayan Ardyan Sudharta Putra, et al.
Published: (2018-05-01)

Association study of relationships of polymorphisms in the miR-21, miR-26b, miR-221/222 and miR-126 genes with cervical intraepithelial neoplasia and cervical cancer
by: Jia Yang, et al.
Published: (2021-09-01)

miR-221/222 targets adiponectin receptor 1 to promote the epithelial-to-mesenchymal transition in breast cancer.
by: Michael S Hwang, et al.
Published: (2013-01-01)

miR-221/222 Promotes S-Phase Entry and Cellular Migration in Control of Basal-Like Breast Cancer
by: Yuan Li, et al.
Published: (2014-05-01)

The inverted pattern of circulating miR-221-3p and miR-222-3p associated with isolated low HDL-C phenotype
by: Yuntao Zhou, et al.
Published: (2018-08-01)

Role of gga-miR-221 and gga-miR-222 during Tumour Formation in Chickens Infected by Subgroup J Avian Leukosis Virus
by: Zhenkai Dai, et al.
Published: (2015-12-01)

miR-221 and miR-222 synergistically regulate hepatocyte growth factor activator inhibitor type 1 to promote cell proliferation and migration in gastric cancer
by: Tao Ning, et al.
Published: (2017-05-01)

Expression of MicroRNAs (miR-15b, miR-16, miR-138, miR-221, and miR-222) as Biomarkers of Endothelial Corpus Cavernosum Dysfunction in a Diabetic Alcoholic Murine Model
by: Ricardo Brianezi Tiraboschi, MD, PhD, et al.
Published: (2021-04-01)

HIV Tat induces expression of ICAM-1 in HUVECs: implications for miR-221/-222 in HIV-associated cardiomyopathy.
by: Ming Duan, et al.
Published: (2013-01-01)

Reck-Notch1 Signaling Mediates miR-221/222 Regulation of Lung Cancer Stem Cells in NSCLC
by: Yuefan Guo, et al.
Published: (2021-04-01)

MiR-221/222 Ameliorates Deoxynivalenol-Induced Apoptosis and Proliferation Inhibition in Intestinal Epithelial Cells by Targeting PTEN
by: Lianjie Hou, et al.
Published: (2021-05-01)

Microrna regulation of anthracycline drug resistance in leukemia through MIR-221, MIR-222, MIR-26a, and MIR-21
by: Gibbs, Seth
Published: (2008)

Necroptosis in Nonalcoholic Steatohepatitis
by: Jérémie Gautheron, PhD, et al.
Published: (2015-05-01)

The role of miR-221 and miR-200a in pterygium pathogenesis.
by: Chueh-Wei Wu, et al.
Published: (2016)

Papillary Thyroid Carcinoma Tissue miR-146b, -21, -221, -222, -181b Expression in Relation with Clinicopathological Features
by: Aistė Kondrotienė, et al.
Published: (2021-03-01)

Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.
by: Sahar Pourhoseini, et al.
Published: (2015-01-01)

Circulating miRNA is a useful diagnostic biomarker for nonalcoholic steatohepatitis in nonalcoholic fatty liver disease
by: Tae Hyung Kim, et al.
Published: (2021-07-01)

miR-221/222 sponge abrogates tamoxifen resistance in ER-positive breast cancer cells through restoring the expression of ERα
by: Yan Xiu Ouyang, et al.
Published: (2021-06-01)

Targeted Inhibition of miR-221/222 Promotes Cell Sensitivity to Cisplatin in Triple-Negative Breast Cancer MDA-MB-231 Cells
by: Shujun Li, et al.
Published: (2020-01-01)

Nonalcoholic Steatohepatitis: An Evolving Diagnosis
by: Brent A Neuschwander-Tetri
Published: (2000-01-01)

The metabolic basis of nonalcoholic steatohepatitis
by: Manu V. Chakravarthy, et al.
Published: (2020-10-01)

Pathogenesis of Nonalcoholic Steatohepatitis: An Overview
by: Gopanandan Parthasarathy, et al.
Published: (2020-04-01)

Liver Fibrogenesis in Nonalcoholic Steatohepatitis
by: Xiong eMa
Published: (2012-07-01)