The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development

The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development

The tumor microenvironment is a complex structure composed of the extracellular matrix (ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune cells). Collagens are the main components of the ECM and they are extensively remodeled during tumor progression. Some collagens...

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Main Authors: Sandra Majo, Patrick Auguste
Format: Article
Language:English
Published: MDPI AG 2021-04-01
Series:Cancers
Subjects:
discoidin domain receptors
extracellular matrix
tumor growth
metastasis
Online Access:https://www.mdpi.com/2072-6694/13/7/1725
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spelling doaj-64ae499d88a54399a216eb72fa562fd02021-04-06T23:00:41ZengMDPI AGCancers2072-66942021-04-01131725172510.3390/cancers13071725The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis DevelopmentSandra Majo0Patrick Auguste1Inserm Bmgic U1035, University of Bordeaux, F-33000 Bordeaux, FranceInserm Bmgic U1035, University of Bordeaux, F-33000 Bordeaux, FranceThe tumor microenvironment is a complex structure composed of the extracellular matrix (ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune cells). Collagens are the main components of the ECM and they are extensively remodeled during tumor progression. Some collagens are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. DDRs are involved in different stages of tumor development and metastasis formation. In this review, we present the different roles of DDRs in these processes and discuss controversial findings. We conclude by describing emerging DDR inhibitory strategies, which could be used as new alternatives for the treatment of patients.https://www.mdpi.com/2072-6694/13/7/1725discoidin domain receptorsextracellular matrixtumor growthmetastasis
collection DOAJ
language English
format Article
sources DOAJ
author Sandra Majo
Patrick Auguste
spellingShingle Sandra Majo
Patrick Auguste
The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development
Cancers
discoidin domain receptors
extracellular matrix
tumor growth
metastasis
author_facet Sandra Majo
Patrick Auguste
author_sort Sandra Majo
title The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development
title_short The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development
title_full The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development
title_fullStr The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development
title_full_unstemmed The Yin and Yang of Discoidin Domain Receptors (DDRs): Implications in Tumor Growth and Metastasis Development
title_sort yin and yang of discoidin domain receptors (ddrs): implications in tumor growth and metastasis development
publisher MDPI AG
series Cancers
issn 2072-6694
publishDate 2021-04-01
description The tumor microenvironment is a complex structure composed of the extracellular matrix (ECM) and nontumoral cells (notably cancer-associated fibroblasts (CAFs) and immune cells). Collagens are the main components of the ECM and they are extensively remodeled during tumor progression. Some collagens are ligands for the discoidin domain receptor tyrosine kinases, DDR1 and DDR2. DDRs are involved in different stages of tumor development and metastasis formation. In this review, we present the different roles of DDRs in these processes and discuss controversial findings. We conclude by describing emerging DDR inhibitory strategies, which could be used as new alternatives for the treatment of patients.
topic discoidin domain receptors
extracellular matrix
tumor growth
metastasis
url https://www.mdpi.com/2072-6694/13/7/1725
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AT sandramajo yinandyangofdiscoidindomainreceptorsddrsimplicationsintumorgrowthandmetastasisdevelopment
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