Reversibility of hAT-MSCs phenotypic and metabolic changes after exposure to and withdrawal from HCC-conditioned medium through regulation of the ROS/MAPK/HIF-1α signaling pathway

Reversibility of hAT-MSCs phenotypic and metabolic changes after exposure to and withdrawal from HCC-conditioned medium through regulation of the ROS/MAPK/HIF-1α signaling pathway

Abstract Background Mesenchymal stem cells (MSCs) play an important role in tumor progression; concomitantly, MSCs also undergo profound changes in the tumor microenvironment (TME). These changes can directly impact the application and efficacy of MSC-based anti-tumor therapy. However, few studies h...

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Bibliographic Details
Main Authors: Chenyang Wang, Jie Hu, Zheng Chen, Yifan Wang, Sinan Lu, Yuan Zhang, Yufeng Li, Yucheng Xiang, Yutian Ji, Cheng Zeng, Yuan Ding, Weilin Wang
Format: Article
Language:English
Published: BMC 2020-11-01
Series:Stem Cell Research & Therapy
Subjects:
Hepatocellular carcinoma
Conditioned medium
Human adipose tissue-derived mesenchymal stem cells
Cell phenotype
Glucose metabolism
Online Access:https://doi.org/10.1186/s13287-020-02010-0

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