Sesquiterpene Lactones and Their Derivatives Inhibit High Glucose-Induced NF-κB Activation and MCP-1 and TGF-β1 Expression in Rat Mesangial Cells

Sesquiterpene Lactones and Their Derivatives Inhibit High Glucose-Induced NF-κB Activation and MCP-1 and TGF-β1 Expression in Rat Mesangial Cells

Diabetic nephropathy (DN) is one of the most common and serious chronic complications of diabetes mellitus, however, no efficient clinical drugs exist for the treatment of DN. We selected and synthesized several sesquiterpene lactones (SLs), and then used the MTT assay to detect rat mesangial cells...

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Bibliographic Details
Main Authors: Hai-Bo Long, Yue Chen, Si-Jia Chen, Jia-Dai Zhai, Quan Zhang, Lian-Bo Wei, Yan Zhao, Qian-Qian Jia, Jian-Cheng Wang, Jing Long
Format: Article
Language:English
Published: MDPI AG 2013-10-01
Series:Molecules
Subjects:
diabetic nephropathy
sesquiterpene lactone
NF-κB
deriviative
sythesis
Online Access:http://www.mdpi.com/1420-3049/18/10/13061

Internet

http://www.mdpi.com/1420-3049/18/10/13061

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