STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium.

STAT2 dependent Type I Interferon response promotes dysbiosis and luminal expansion of the enteric pathogen Salmonella Typhimurium.

The mechanisms by which the gut luminal environment is disturbed by the immune system to foster pathogenic bacterial growth and survival remain incompletely understood. Here, we show that STAT2 dependent type I IFN signaling contributes to the inflammatory environment by disrupting hypoxia enabling...

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Bibliographic Details
Main Authors: R Paul Wilson, Sarah A Tursi, Glenn J Rapsinski, Nicole J Medeiros, Long S Le, Kevin P Kotredes, Sajan Patel, Elisabetta Liverani, Shuang Sun, Wenhan Zhu, Laurie Kilpatrick, Sebastian E Winter, Ana M Gamero, Çagla Tükel
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007745

Internet

https://doi.org/10.1371/journal.ppat.1007745

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